Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade extracellular matrix (ECM), thus assisting invasion. Upregulation of MMPs, frequently reported in gliomas, is associated with aggressive behavior. WNK2 is a tumor suppressor gene expressed in normal brain, and silenced by promoter...

Full description

Bibliographic Details
Main Author: Costa, Angela Margarida (author)
Other Authors: Pinto, Filipe (author), Martinho, Olga (author), Oliveira, Maria José (author), Jordan, Peter (author), Reis, R. M. (author)
Format: article
Language:eng
Published: 2015
Subjects:
Brain Neoplasms
Cell Line, Tumor
Down-Regulation
Glioma
Humans
MAP Kinase Kinase 4
Matrix Metalloproteinase 2
Neoplasm Invasiveness
Protein-Serine-Threonine Kinases
Transcriptional Activation
Up-Regulation
Gene Silencing
Genes, Tumor Suppressor
Online Access:http://hdl.handle.net/1822/62215
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/62215

Internet

http://hdl.handle.net/1822/62215

Similar Items