Structure-activity relationships for dipeptide prodrugs of acyclovir

A series of water-soluble dipeptide ester prodrugs of the antiviral acyclovir (ACV) were evaluated for their chemical stability, cytotoxicity, and antiviral activity against several strains of Herpes Simplex-1 and -2, vaccinia, vesicular stomatitis, cytomegalovirus and varicella zoster viruses. ACV...

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Bibliographic Details
Main Author: Santos, Cledir R. (author)
Other Authors: Capela, Rita (author), Pereira, Claudia S. G. P. (author), Valente, Emilia (author), Gouveia, Luis (author), Pannecouque, Christophe (author), De Clercq, Erik (author), Moreira, Rui (author), Gomes, Paula (author)
Format: article
Language:eng
Published: 2015
Subjects:
Chemistry, Medicinal
Online Access:http://hdl.handle.net/10451/21170
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21170

Internet

http://hdl.handle.net/10451/21170

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