The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design

The de novo crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1 (LiSir2rp1) has been solved at 1.99Å in complex with an acetyl-lysine peptide substrate. The structure is broadly commensurate with Hst2/SIRT2 proteins of yeast and human origin, reproducing man...

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Bibliographic Details
Main Author: Ronin, C (author)
Other Authors: Costa, DM (author), Tavares, J (author), Faria, J (author), Ciesielski, F (author), Ciapetti, P (author), Smith, TK (author), MacDougall, J (author), Cordeiro-da-Silva, A (author), Pemberton, I (author)
Format: article
Language:eng
Published: 2018
Online Access:https://hdl.handle.net/10216/127391
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/127391

Internet

https://hdl.handle.net/10216/127391

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