Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53

Drug resistance to 5-fluorouracil (5-FU) is still a major limitation to its clinical use. In addition, the clinical value of p53 as a predictive marker for 5-FU-based chemotherapy remains a matter of debate. Here, we used HCTI 16 human colorectal cancer c

Detalhes bibliográficos
Autor principal: Borralho, Pedro M. (author)
Outros Autores: da Silva, Isabel B. Moreira (author), Aranha, Marcia M. (author), Albuquerque, Cristina (author), Leitao, Carlos Nobre (author), Steer, Clifford J. (author), Rodrigues, Cecilia M. P. (author)
Formato: article
Idioma:eng
Publicado em: 2015
Assuntos:
Biochemistry & Molecular Biology
Biophysics
Cell Biology
Texto completo:http://hdl.handle.net/10451/21088
País:Portugal
Oai:oai:repositorio.ul.pt:10451/21088
Descrição
Resumo:Drug resistance to 5-fluorouracil (5-FU) is still a major limitation to its clinical use. In addition, the clinical value of p53 as a predictive marker for 5-FU-based chemotherapy remains a matter of debate. Here, we used HCTI 16 human colorectal cancer c

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