Cationic polyene phospholipids as DNA carriers for ocular gene therapy

Recent success in the treatment of congenital blindness demonstrates the potential of ocular gene therapy as a therapeutic approach. The eye is a good target due to its small size, minimal diffusion of therapeutic agent to the systemic circulation, and low immune and inflammatory responses. Currentl...

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Bibliographic Details
Main Author: Machado, Susana (author)
Other Authors: Calado, Sofia (author), Bitoque, Diogo (author), Oliveira, Ana Vanessa (author), Øpstad, Christer L. (author), Zeeshan, Muhammad (author), Sliwka, Hans-Richard (author), Partali, Vassilia (author), Pungente, Michael D. (author), Silva, Gabriela (author)
Format: article
Language:eng
Published: 2017
Subjects:
Cations
Cell line
Cholesterol
DNA
Epithelium, corneal
Eye
Gene transfer techniques
Genetic therapy
Genetic vectors
Humans
Liposomes
Phosphatidylethanolamines
Phospholipids
Plasmids
Polyenes
Retinal pigments
Transfection
Online Access:http://hdl.handle.net/10400.1/9874
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/9874

Internet

http://hdl.handle.net/10400.1/9874

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