Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances

If misregulated, macrophage (M)T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-M (GM-CSF)- and M colony-stimulating factor (M-CSF)-dependent Ms have dichotomous effects on T c...

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Bibliographic Details
Main Author: Ohradanova-Repic, Anna (author)
Other Authors: Machacek, Christian (author), Charvet, Celine (author), Lager, Franck (author), Le Roux, Delphine (author), Platzer, René (author), Leksa, Vladimir (author), Mitulovic, Goran (author), Burkard, Thomas R. (author), Zlabinger, Gerhard J. (author), Fischer, Michael B. (author), Feuillet, Vincent (author), Renault, Gilles (author), Blüml, Stephan (author), Benko, Miroslav (author), Suchanek, Miloslav (author), Huppa, Johannes B. (author), Matsuyama, Takami (author), Cavaco-Paulo, Artur (author), Bismuth, Georges (author), Stockinger, Hannes (author)
Format: article
Language:eng
Published: 2018
Subjects:
macrophage polarization
chronic inflammation
macrophage-T cell interaction
purine metabolism
adenosine
methotrexate
rheumatoid arthritis
Science & Technology
Online Access:http://hdl.handle.net/1822/54611
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/54611

Internet

http://hdl.handle.net/1822/54611

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