Extracellular purine metabolism is the switchboard of immunosuppressive macrophages and a novel target to treat diseases with macrophage imbalances

If misregulated, macrophage (M)T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-M (GM-CSF)- and M colony-stimulating factor (M-CSF)-dependent Ms have dichotomous effects on T c...

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Detalhes bibliográficos
Autor principal: Ohradanova-Repic, Anna (author)
Outros Autores: Machacek, Christian (author), Charvet, Celine (author), Lager, Franck (author), Le Roux, Delphine (author), Platzer, René (author), Leksa, Vladimir (author), Mitulovic, Goran (author), Burkard, Thomas R. (author), Zlabinger, Gerhard J. (author), Fischer, Michael B. (author), Feuillet, Vincent (author), Renault, Gilles (author), Blüml, Stephan (author), Benko, Miroslav (author), Suchanek, Miloslav (author), Huppa, Johannes B. (author), Matsuyama, Takami (author), Cavaco-Paulo, Artur (author), Bismuth, Georges (author), Stockinger, Hannes (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
macrophage polarization
chronic inflammation
macrophage-T cell interaction
purine metabolism
adenosine
methotrexate
rheumatoid arthritis
Science & Technology
Texto completo:http://hdl.handle.net/1822/54611
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/54611

Texto Completo

http://hdl.handle.net/1822/54611

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