Effect of Amphipathic HIV Fusion Inhibitor Peptides on POPC and POPC/Cholesterol Membrane Properties: A Molecular Simulation Study

T-20 and T-1249 fusion inhibitor peptides were shown to interact with 1-palmitoyl-2-oleyl-phosphatidylcholine (POPC) (liquid disordered, ld) and POPC/cholesterol (1:1) (POPC/Chol) (liquid ordered, lo) bilayers, and they do so to different extents. Although they both possess a tryptophan-rich domain...

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Bibliographic Details
Main Author: Martins do Canto, Antonio Manuel Teixeira (author)
Other Authors: Carvalho, Alfredo Jorge Palace (author), Ramalho, João Paulo Prates (author), Loura, Luís Miguel Santos (author)
Format: article
Language:por
Published: 2013
Subjects:
gp41 domain
enfuvirtide
cholesterol
cell entry
model membranes
phospholipid-bilayers
Online Access:http://hdl.handle.net/10174/8750
Country:Portugal
Oai:oai:dspace.uevora.pt:10174/8750

Internet

http://hdl.handle.net/10174/8750

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