Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer

Aberrant activation of telomerase in human cancer is achieved by various alterations within the TERT promoter, including cancer-specific DNA hypermethylation of the TERT hypermethylated oncological region (THOR). However, the impact of allele-specific DNA methylation within the TERT promoter on gene...

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Detalhes bibliográficos
Autor principal: Lee, Donghyun D. (author)
Outros Autores: Komosa, Martin (author), Sudhaman, Sumedha (author), Leão, Ricardo (author), Zhang, Cindy H. (author), Apolonio, Joana D. (author), Hermanns, Thomas (author), Wild, Peter J. (author), Klocker, Helmut (author), Nassiri, Farshad (author), Zadeh, Gelareh (author), Diplas, Bill H. (author), Yan, Hai (author), Gallinger, Steven (author), Pugh, Trevor J. (author), Ramaswamy, Vijay (author), Taylor, Michael D. (author), Castelo-Branco, Pedro (author), Nunes, Nuno Miguel (author), Tabori, Uri (author)
Formato: article
Idioma:eng
Publicado em: 2021
Assuntos:
Mutações do promotor
Metilação
Expressão
Telômeros
Texto completo:http://hdl.handle.net/10400.1/17348
País:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/17348

Texto Completo

http://hdl.handle.net/10400.1/17348

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