Dual role of allele-specific DNA hypermethylation within the TERT promoter in cancer

Aberrant activation of telomerase in human cancer is achieved by various alterations within the TERT promoter, including cancer-specific DNA hypermethylation of the TERT hypermethylated oncological region (THOR). However, the impact of allele-specific DNA methylation within the TERT promoter on gene...

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Bibliographic Details
Main Author: Lee, Donghyun D. (author)
Other Authors: Komosa, Martin (author), Sudhaman, Sumedha (author), Leão, Ricardo (author), Zhang, Cindy H. (author), Apolonio, Joana D. (author), Hermanns, Thomas (author), Wild, Peter J. (author), Klocker, Helmut (author), Nassiri, Farshad (author), Zadeh, Gelareh (author), Diplas, Bill H. (author), Yan, Hai (author), Gallinger, Steven (author), Pugh, Trevor J. (author), Ramaswamy, Vijay (author), Taylor, Michael D. (author), Castelo-Branco, Pedro (author), Nunes, Nuno Miguel (author), Tabori, Uri (author)
Format: article
Language:eng
Published: 2021
Subjects:
Mutações do promotor
Metilação
Expressão
Telômeros
Online Access:http://hdl.handle.net/10400.1/17348
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/17348

Internet

http://hdl.handle.net/10400.1/17348

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