An in vivo evaluation of the potential of 188Re-PEI-MP for therapy of bladder carcinoma and 99mTc-PEI-MP for diagnosis and follow up

The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respect...

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Bibliographic Details
Main Author: Ferreira, Sara (author)
Other Authors: Laranjo, Mafalda (author), Abrantes, Ana Margarida (author), Brito, Ana (author), Pires, Salomé (author), Metello, Luís F. (author), Zeevart, Jan (author), Louw, Werner (author), Dormehl, Irene (author), Botelho, Maria Filomena (author)
Format: other
Language:eng
Published: 2015
Online Access:http://hdl.handle.net/10400.22/6457
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/6457
Description
Summary:The development of water-soluble polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate groups) that might be labeled with 188Re (emits of high energy beta particles) and 99mTc are recent approaches, with a strong potential for metabolic radiotherapy and diagnosis, respectively. The aim of this study was to evaluate the efficacy of 188Re-PEI-MP as therapeutic agent for bladder carcinoma and 99mTc-PEI-MP for its diagnosis and follow up.

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