Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

A new family of gene delivery vectors is synthesized consisting of a medium-size generation PAMAM dendrimer (generation 5, with amine termini) core randomly linked at the periphery to hydrophobic chains that vary in length (12 to 16 carbon alkyl chains) and number (from 4.2 to 9.7 in average). The i...

Full description

Bibliographic Details
Main Author: Santos, José L. (author)
Other Authors: Oliveira, Hugo (author), Pandita, Deepti (author), Rodrigues, João (author), Pêgo, Ana P. (author), Granja, Pedro L. (author), Tomás, Helena (author)
Format: article
Language:eng
Published: 2019
Subjects:
Poly(amidoamine) dendrimer
Gene delivery
Mesenchymal stem cells
Cellular uptake
Biomedical applications
.
Faculdade de Ciências Exatas e da Engenharia
Online Access:http://hdl.handle.net/10400.13/2400
Country:Portugal
Oai:oai:digituma.uma.pt:10400.13/2400

Internet

http://hdl.handle.net/10400.13/2400

Similar Items