Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

A new family of gene delivery vectors is synthesized consisting of a medium-size generation PAMAM dendrimer (generation 5, with amine termini) core randomly linked at the periphery to hydrophobic chains that vary in length (12 to 16 carbon alkyl chains) and number (from 4.2 to 9.7 in average). The i...

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Detalhes bibliográficos
Autor principal: Santos, José L. (author)
Outros Autores: Oliveira, Hugo (author), Pandita, Deepti (author), Rodrigues, João (author), Pêgo, Ana P. (author), Granja, Pedro L. (author), Tomás, Helena (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Poly(amidoamine) dendrimer
Gene delivery
Mesenchymal stem cells
Cellular uptake
Biomedical applications
.
Faculdade de Ciências Exatas e da Engenharia
Texto completo:http://hdl.handle.net/10400.13/2400
País:Portugal
Oai:oai:digituma.uma.pt:10400.13/2400

Texto Completo

http://hdl.handle.net/10400.13/2400

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