Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65years) Alzheimer’s disease (AD). We performed a screening for mutations in the coding regions of presenilins, as well as exons 16 and 17 of the APP gene in a total of 231 patients from the Iberi...

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Bibliographic Details
Main Author: Guerreiro, Rita João (author)
Other Authors: Baquero, Miquel (author), Blesa, Rafael (author), Boada, Mercè (author), Brás, José Miguel (author), Bullido, Maria. J. (author), Calado, Ana (author), Crook, Richard (author), Ferreira, Carla (author), Frank, Ana (author), Gómez-Isla, Teresa (author), Hernández, Isabel (author), Lleó, Alberto (author), Machado, Álvaro (author), Martínez- Lage, Pablo (author), Masdeu, José (author), Molina-Porcel, Laura (author), Molinuevo, José L. (author), Pastor, Pau (author), Pérez-Tur, Jordi (author), Relvas, Rute (author), Oliveira, Catarina Resende (author), Ribeiro, Maria Helena (author), Rogaeva, Ekaterina (author), Sá, Alfredo (author), Samaranch, Lluís (author), Sánchez-Valle, Raquel (author), Santana, Isabel (author), Tàrraga, Lluís (author), Valdivieso, Fernando (author), Singleton, Andrew (author), Hardy, John (author), Clarimón, Jordi (author)
Format: article
Language:eng
Published: 2010
Subjects:
Early-onset Alzheimer’s disease
Presenilins
APP
Mutations
Online Access:http://hdl.handle.net/10316/20129
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/20129

Internet

http://hdl.handle.net/10316/20129

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