Genetic screening of Alzheimer's disease genes in Iberian and African samples yields novel mutations in presenilins and APP

Mutations in three genes (PSEN1, PSEN2, and APP) have been identified in patients with early-onset (<65years) Alzheimer’s disease (AD). We performed a screening for mutations in the coding regions of presenilins, as well as exons 16 and 17 of the APP gene in a total of 231 patients from the Iberi...

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Detalhes bibliográficos
Autor principal: Guerreiro, Rita João (author)
Outros Autores: Baquero, Miquel (author), Blesa, Rafael (author), Boada, Mercè (author), Brás, José Miguel (author), Bullido, Maria. J. (author), Calado, Ana (author), Crook, Richard (author), Ferreira, Carla (author), Frank, Ana (author), Gómez-Isla, Teresa (author), Hernández, Isabel (author), Lleó, Alberto (author), Machado, Álvaro (author), Martínez- Lage, Pablo (author), Masdeu, José (author), Molina-Porcel, Laura (author), Molinuevo, José L. (author), Pastor, Pau (author), Pérez-Tur, Jordi (author), Relvas, Rute (author), Oliveira, Catarina Resende (author), Ribeiro, Maria Helena (author), Rogaeva, Ekaterina (author), Sá, Alfredo (author), Samaranch, Lluís (author), Sánchez-Valle, Raquel (author), Santana, Isabel (author), Tàrraga, Lluís (author), Valdivieso, Fernando (author), Singleton, Andrew (author), Hardy, John (author), Clarimón, Jordi (author)
Formato: article
Idioma:eng
Publicado em: 2010
Assuntos:
Early-onset Alzheimer’s disease
Presenilins
APP
Mutations
Texto completo:http://hdl.handle.net/10316/20129
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/20129

Texto Completo

http://hdl.handle.net/10316/20129

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