Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of rab27a

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is important in targeting Rabs to specific membranes. He...

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Detalhes bibliográficos
Autor principal: Sanza, Paolo (author)
Outros Autores: Evans, Richard D. (author), Briggs, Deborah A. (author), Cantero, Marta (author), Montoliu, Lluis (author), Patel, Shyamal (author), Sviderskaya, Elena V. (author), Itzen, Aymelt (author), Figueiredo, Ana C. (author), Seabra, Miguel C. (author), Hume, Alistair N. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Guanine nucleotide exchange factor
MADD
Melanocyte
Organelle transport
Rab27a
Rab3GEP
Cell Biology
Texto completo:https://doi.org/10.1242/jcs.212035
País:Portugal
Oai:oai:run.unl.pt:10362/70290

Texto Completo

https://doi.org/10.1242/jcs.212035

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