Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of rab27a

Rab GTPases are compartment-specific molecular switches that regulate intracellular vesicular transport in eukaryotes. GDP/GTP exchange factors (GEFs) control Rab activation, and current models propose that localised and regulated GEF activity is important in targeting Rabs to specific membranes. He...

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Bibliographic Details
Main Author: Sanza, Paolo (author)
Other Authors: Evans, Richard D. (author), Briggs, Deborah A. (author), Cantero, Marta (author), Montoliu, Lluis (author), Patel, Shyamal (author), Sviderskaya, Elena V. (author), Itzen, Aymelt (author), Figueiredo, Ana C. (author), Seabra, Miguel C. (author), Hume, Alistair N. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Guanine nucleotide exchange factor
MADD
Melanocyte
Organelle transport
Rab27a
Rab3GEP
Cell Biology
Online Access:https://doi.org/10.1242/jcs.212035
Country:Portugal
Oai:oai:run.unl.pt:10362/70290

Internet

https://doi.org/10.1242/jcs.212035

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