m5U54 tRNA hypomodification by lack of TRMT2A drives the generation of tRNA-derived small RNAs

Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regul...

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Bibliographic Details
Main Author: Pereira, Marisa (author)
Other Authors: Ribeiro, Diana R. (author), Pinheiro, Miguel M. (author), Ferreira, Margarida (author), Kellner, Stefanie (author), Soares, Ana R. (author)
Format: article
Language:eng
Published: 2021
Subjects:
tRNAs
tRNA-modifying enzyme
TRMT2A
Methyltransferase
tRNA hypomethylation
tRNA-derived small RNAs
tRNA-derived stress-induced RNAs
Angiogenin
Online Access:http://hdl.handle.net/10773/31142
Country:Portugal
Oai:oai:ria.ua.pt:10773/31142

Internet

http://hdl.handle.net/10773/31142

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