Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study

The first structure–activity relationship study of vinyl sulfones as caspase-3 inhibitors is reported. A series of 12 vinyl sulfones was synthesized and evaluated for two downstream caspases (caspases-3 and -7). Dipeptidyl derivatives were significantly superior to their counterparts containing only...

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Bibliographic Details
Main Author: Newton, Ana S. (author)
Other Authors: Glória, Paulo M. C. (author), Gonçalves, Lídia M. (author), Santos, Daniel J. V. A. dos (author), Moreira, Rui (author), Guedes, Rita C. (author), Santos, Maria M. M. (author)
Format: article
Language:eng
Published: 2011
Subjects:
Vinyl sulfone
Caspase-3 inhibitor
Michael acceptor
Irreversible inhibitor
Online Access:http://hdl.handle.net/10451/3844
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/3844

Internet

http://hdl.handle.net/10451/3844

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