Time course and mechanisms of left ventricular systolic and diastolic dysfunction in monocrotaline-induced pulmonary hypertension

Although pulmonary hypertension (PH) selectively overloads the right ventricle (RV), neuroendocrine activation and intrinsic myocardial dysfunction have been described in the left ventricle (LV). In order to establish the timing of LV dysfunction development in PH and to clarify underlying molecular...

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Bibliographic Details
Main Author: Correia-Pinto, Jorge (author)
Other Authors: Henriques-Coelho, Tiago (author), Roncon-Albuquerque, Roberto (author), Lourenço, André P. (author), Rocha, Gustavo Filipe Melo Alves (author), Vasques-Nóvoa, Francisco (author), Gillebert, Thierry C. (author), Leite-Moreira, Adelino F. (author)
Format: article
Language:eng
Published: 2009
Subjects:
Animals
Apoptosis
Collagen
Diastole
Disease Models, Animal
Endothelin-1
Hypertension, Pulmonary
Male
Monocrotaline
Myocardium
Myosin Heavy Chain
Peptidyl-Dipeptidase A
RNA, Messenger
Rats
Rats, Wistar
Systole
Tenascin-C
Time Factors
Ventricular Dysfunction, Left
Myocardial Contraction
Ventricular Pressure
Angiotensin-converting enzyme
Online Access:http://hdl.handle.net/1822/67582
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67582

Internet

http://hdl.handle.net/1822/67582

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