Cancer syndromes and therapy by stop-codon readthrough

Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as ami...

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Bibliographic Details
Main Author: Bordeira-Carriço, Renata (author)
Other Authors: Pêgo, Ana Paula (author), Santos, Manuel (author), Oliveira, Carla (author)
Format: article
Language:eng
Published: 2019
Subjects:
Aminoglycosides
Hereditary cancer syndromes
Nonsense-suppression
PTC124
Readthrough
Suppressor-tRNA
Nonsense-mediated decay (NMD)
Premature termination codon (PTC)
Online Access:http://hdl.handle.net/10773/26583
Country:Portugal
Oai:oai:ria.ua.pt:10773/26583

Internet

http://hdl.handle.net/10773/26583

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