Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Huntington's disease (HD) is an inherited neurodegenerative disease caused by a polyglutamine repeat expansion in the huntingtin protein. Mitochondrial dysfunction associated with energy failure plays an important role in this untreated pathology. In the present work, we used lymphoblasts obtai...

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Bibliographic Details
Main Author: Naia, Luana (author)
Other Authors: Ferreira, I. Luísa (author), Cunha-Oliveira, Teresa (author), Duarte, Ana I. (author), Ribeiro, Márcio (author), Rosenstock, Tatiana R. (author), Laço, Mário N. (author), Ribeiro, Maria J. (author), Oliveira, Catarina R. (author), Saudou, Frédéric (author), Humbert, Sandrine (author), Rego, A. Cristina (author)
Format: article
Language:eng
Published: 2015
Subjects:
Animals
Calcium
Cell Line
Cytochromes c
Electron Transport
Extracellular Signal-Regulated MAP Kinases
Female
Humans
Huntingtin Protein
Huntington Disease
Insulin
Insulin-Like Growth Factor I
Lymphocytes
Male
Membrane Potential, Mitochondrial
Mitochondria
Nerve Tissue Proteins
Oxygen Consumption
Phosphorylation
Receptor, IGF Type 1
Sus scrofa
Energy Metabolism
Signal Transduction
Online Access:http://hdl.handle.net/10316/41106
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/41106

Internet

http://hdl.handle.net/10316/41106

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