The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For the...

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Bibliographic Details
Main Author: Gomes, Ana Sara (author)
Other Authors: Trovão, Filipa (author), Andrade Pinheiro, Benedita (author), Freire, Filipe (author), Gomes, Sara (author), Oliveira, Carla (author), Domingues, Lucília (author), Romão, Maria João (author), Saraiva, Lucília (author), Carvalho, Ana Luísa (author)
Format: article
Language:eng
Published: 2018
Subjects:
mutant p53R280K
crystal structure
DNA binding
anticancer therapy
Science & Technology
Online Access:http://hdl.handle.net/1822/54422
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/54422

Internet

http://hdl.handle.net/1822/54422

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