The Crystal Structure of the R280K Mutant of Human p53 Explains the Loss of DNA Binding

The p53 tumor suppressor is widely found to be mutated in human cancer. This protein is regarded as a molecular hub regulating different cell responses, namely cell death. Compelling data have demonstrated that the impairment of p53 activity correlates with tumor development and maintenance. For the...

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Detalhes bibliográficos
Autor principal: Gomes, Ana Sara (author)
Outros Autores: Trovão, Filipa (author), Andrade Pinheiro, Benedita (author), Freire, Filipe (author), Gomes, Sara (author), Oliveira, Carla (author), Domingues, Lucília (author), Romão, Maria João (author), Saraiva, Lucília (author), Carvalho, Ana Luísa (author)
Formato: article
Idioma:eng
Publicado em: 2018
Assuntos:
mutant p53R280K
crystal structure
DNA binding
anticancer therapy
Science & Technology
Texto completo:http://hdl.handle.net/1822/54422
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/54422

Texto Completo

http://hdl.handle.net/1822/54422

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