Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma

HOXA genes encode critical transcriptional regulators of embryonic development that have been implicated in cancer. In this study, we documented functional relevance and mechanism of activation of HOXA9 in glioblastoma (GBM), the most common malignant brain tumor. Expression of HOXA genes was invest...

Full description

Bibliographic Details
Main Author: Costa, Bruno Marques (author)
Other Authors: Smith, Justin S. (author), Chen, Ying (author), Chen, Justin (author), Phillips, Heidi S. (author), Aldape, Kenneth D. (author), Zardo, Giuseppe (author), Nigro, Janice (author), James, C. David (author), Fridlyand, Jane (author), Reis, R. M. (author), Costello, Joseph F. (author)
Format: article
Language:eng
Published: 2010
Subjects:
Adult
Apoptosis
Astrocytoma
Brain Neoplasms
Cell Growth Processes
DNA Modification Methylases
DNA Repair Enzymes
Disease-Free Survival
Epigenesis, Genetic
Glioblastoma
Histones
Homeodomain Proteins
Humans
Phosphatidylinositol 3-Kinases
Promoter Regions, Genetic
Survival Rate
Transcriptional Activation
Tumor Suppressor Proteins
Gene Expression Regulation, Neoplastic
Phosphoinositide-3 Kinase Inhibitors
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/67536
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67536

Internet

http://hdl.handle.net/1822/67536

Similar Items