Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma

HOXA genes encode critical transcriptional regulators of embryonic development that have been implicated in cancer. In this study, we documented functional relevance and mechanism of activation of HOXA9 in glioblastoma (GBM), the most common malignant brain tumor. Expression of HOXA genes was invest...

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Detalhes bibliográficos
Autor principal: Costa, Bruno Marques (author)
Outros Autores: Smith, Justin S. (author), Chen, Ying (author), Chen, Justin (author), Phillips, Heidi S. (author), Aldape, Kenneth D. (author), Zardo, Giuseppe (author), Nigro, Janice (author), James, C. David (author), Fridlyand, Jane (author), Reis, R. M. (author), Costello, Joseph F. (author)
Formato: article
Idioma:eng
Publicado em: 2010
Assuntos:
Adult
Apoptosis
Astrocytoma
Brain Neoplasms
Cell Growth Processes
DNA Modification Methylases
DNA Repair Enzymes
Disease-Free Survival
Epigenesis, Genetic
Glioblastoma
Histones
Homeodomain Proteins
Humans
Phosphatidylinositol 3-Kinases
Promoter Regions, Genetic
Survival Rate
Transcriptional Activation
Tumor Suppressor Proteins
Gene Expression Regulation, Neoplastic
Phosphoinositide-3 Kinase Inhibitors
Ciências Médicas::Medicina Básica
Science & Technology
Texto completo:http://hdl.handle.net/1822/67536
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67536

Texto Completo

http://hdl.handle.net/1822/67536

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