Familial thyroid cancer : identification of novel susceptibility genes

Thyroid cancer is the most common malignancy of the endocrine system. The majority of thyroid cancers derive from the follicular cells, being designated as non-medullary thyroid carcinomas (NMTC). NMTC also occurs in a familial form, entitled familial non-medullary thyroid carcinoma (FNMTC), represe...

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Bibliographic Details
Main Author: Marques, Inês Filipa Jorge Reis (author)
Format: doctoralThesis
Language:eng
Published: 2022
Subjects:
Thyroid
Familial non-medullary thyroid carcinoma (FNMTC)
SPRY4
DNA repair genes
DICER1
TERT promoter
whole-exome sequencing (WES)
next-generation sequencing (NGS)
FNMTC aetiology
tumour progression
Tiróide
Carcinoma não-medular da tiróide familiar (FNMTC)
genes de reparação do DNA
promotor do TERT
sequenciação global do exoma (WES)
sequenciação de nova geração (NGS)
etiologia do FNMTC
progressão tumoral
Domínio/Área Científica::Ciências Médicas
Online Access:http://hdl.handle.net/10362/68971
Country:Portugal
Oai:oai:run.unl.pt:10362/68971

Internet

http://hdl.handle.net/10362/68971

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