Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The a...

ver descrição completa

Detalhes bibliográficos
Autor principal: Calhelha, Ricardo C. (author)
Outros Autores: Ferreira, Isabel C. F. R. (author), Peixoto, Daniela (author), Abreu, Rui M. V. (author), Silva, L. A. Vale (author), Pinto, Eugénia (author), Lima, Raquel T. (author), Alvelos, Maria I. (author), Vasconcelos, M. Helena (author), Queiroz, Maria João R. P. (author)
Formato: article
Idioma:eng
Publicado em: 2012
Assuntos:
Thieno[3,2-b]pyridines
Aminodi(hetero)arylamines
Buchwald-hartwig C-N coupling
Antitumoral activity
Toxicity
Cell cycle
Apoptosis
2-b]pyridines
Thieno[3
Science & Technology
Texto completo:http://hdl.handle.net/1822/22006
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/22006

Texto Completo

http://hdl.handle.net/1822/22006

Registros relacionados