Aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series: synthesis, effects in human tumor cells growth, cell cycle analysis, apoptosis and evaluation of toxicity using non-tumor cells

Three aminodi(hetero)arylamines were prepared via a palladium-catalyzed C-N Buchwald-Hartwig coupling of methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate with different bromonitrobenzenes, followed by reduction of the nitro groups of the coupling products to the corresponding amino compounds. The a...

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Bibliographic Details
Main Author: Calhelha, Ricardo C. (author)
Other Authors: Ferreira, Isabel C. F. R. (author), Peixoto, Daniela (author), Abreu, Rui M. V. (author), Silva, L. A. Vale (author), Pinto, Eugénia (author), Lima, Raquel T. (author), Alvelos, Maria I. (author), Vasconcelos, M. Helena (author), Queiroz, Maria João R. P. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Thieno[3,2-b]pyridines
Aminodi(hetero)arylamines
Buchwald-hartwig C-N coupling
Antitumoral activity
Toxicity
Cell cycle
Apoptosis
2-b]pyridines
Thieno[3
Science & Technology
Online Access:http://hdl.handle.net/1822/22006
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/22006

Internet

http://hdl.handle.net/1822/22006

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