Hormone affinity and fibril formation of piscine transthyretin: the role of the N-terminal

Transthyretin (TTR) transports thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3) in the blood of vertebrates. TH-binding sites are highly conserved in vertebrate TTR however, piscine TTR has a longer N-terminus which is thought to influence TH-binding affinity and may influence TTR st...

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Bibliographic Details
Main Author: Morgado, Isabel (author)
Other Authors: Melo, Eduardo P. (author), Lundberg, Erik (author), Estrela, Nídia L. (author), Sauer-Eriksson, A. Elisabeth (author), Power, Deborah (author)
Format: article
Language:eng
Published: 2014
Subjects:
Amyloid fibrils
Recombinant protein
Ligand binding characteristics
Transthyretin
TTR tetramer stability
Online Access:http://hdl.handle.net/10400.1/5419
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/5419

Internet

http://hdl.handle.net/10400.1/5419

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