Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 Cells

Amyloid beta-peptide (Abeta)-induced cell death may involve activation of the E2F-1 transcription factor and other cell cycle-related proteins. In previous studies, we have shown that tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates A

Bibliographic Details
Main Author: Ramalho, RM (author)
Other Authors: Ribeiro, PS (author), Sola, S (author), Castro, RE (author), Steer, CJ (author), Rodrigues, CMP (author)
Format: article
Language:eng
Published: 2015
Subjects:
Biochemistry & Molecular Biology
Neurosciences
Online Access:http://hdl.handle.net/10451/21071
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/21071
Description
Summary:Amyloid beta-peptide (Abeta)-induced cell death may involve activation of the E2F-1 transcription factor and other cell cycle-related proteins. In previous studies, we have shown that tauroursodeoxycholic acid (TUDCA), an endogenous bile acid, modulates A

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