Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk

Glioblastoma (GBM) is one of the most glycolytic and angiogenic human tumors, characteristics that contribute to the poor prognosis associated with this type of tumor. A lactate shuttle has been described between tumor cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) a...

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Bibliographic Details
Main Author: Miranda-Gonçalves, Vera (author)
Other Authors: Bezerra, Filipa (author), Costa-Almeida, Raquel (author), Freitas-Cunha, Marta (author), Soares, Raquel (author), Martinho, Olga (author), Reis, R. M. (author), Pinheiro, Céline (author), Baltazar, Fátima (author)
Format: article
Language:eng
Published: 2017
Subjects:
Blotting, Western
Brain Neoplasms
Cell Line, Tumor
Cell Movement
Cell Proliferation
Culture Media, Conditioned
Endothelial Cells
Glioma
Humans
Lactic Acid
Monocarboxylic Acid Transporters
Neovascularization, Pathologic
RNA Interference
Signal Transduction
Symporters
Tumor Microenvironment
Angiogenesis
Glioma cells
Lactate
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/67153
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67153

Internet

http://hdl.handle.net/1822/67153

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