Synthesis and antioxidant activity of new methoxylated di(hetero)arylamines derivatives of thieno[3,2-b]pyridines,
Due to their isosterism with pyrrolopyridines or quinolines, thieno[3,2-b]pyridines have attracted much attention because of their potential biological activity [1]. We have prepared the 6-bromothieno[3,2-b]pyridine 1, following a known method used by us for benzo[b]thiophene compounds [2], as compo...
| Autor principal: | |
|---|---|
| Outros Autores: | , , |
| Formato: | conferenceObject |
| Idioma: | eng |
| Publicado em: |
2011
|
| Texto completo: | http://hdl.handle.net/10198/3708 |
| País: | Portugal |
| Oai: | oai:bibliotecadigital.ipb.pt:10198/3708 |
| Resumo: | Due to their isosterism with pyrrolopyridines or quinolines, thieno[3,2-b]pyridines have attracted much attention because of their potential biological activity [1]. We have prepared the 6-bromothieno[3,2-b]pyridine 1, following a known method used by us for benzo[b]thiophene compounds [2], as component for palladium-catalyzed Buchwald-Hartwig coupling with methoxylated ani lines. The corresponding di(hetero)arylamines 2a-2d were obtained in good yields and were fully characterized (Scheme 1). |
|---|