Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B∗27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,64...

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Detalhes bibliográficos
Autor principal: Cortes, Adrian (author)
Outros Autores: Pulit, Sara L. (author), Leo, Paul J. (author), Pointon, Jenny J. (author), Robinson, Philip C. (author), Weisman, Michael H. (author), Ward, Michael (author), Gensler, Lianne S. (author), Zhou, Xiaodong (author), Garchon, Henri Jean (author), Chiocchia, Gilles (author), Nossent, Johannes (author), Lie, Benedicte A. (author), Førre, Øystein (author), Tuomilehto, Jaakko (author), Laiho, Kari (author), Bradbury, Linda A. (author), Elewaut, Dirk (author), Burgos-Vargas, Ruben (author), Stebbings, Simon (author), Appleton, Louise (author), Farrah, Claire (author), Lau, Jonathan (author), Haroon, Nigil (author), Mulero, Juan (author), Blanco, Francisco J. (author), Gonzalez-Gay, Miguel A. (author), Lopez-Larrea, C. (author), Bowness, Paul (author), Gaffney, Karl (author), Gaston, Hill (author), Gladman, Dafna D. (author), Rahman, Proton (author), Maksymowych, Walter P. (author), Crusius, J. Bart A (author), Van Der Horst-Bruinsma, Irene E. (author), Valle-Oñate, Raphael (author), Romero-Sánchez, Consuelo (author), Hansen, Inger Myrnes (author), Pimentel-Santos, Fernando M. (author), Inman, Robert D. (author), Martin, Javier (author), Breban, Maxime (author), Wordsworth, Bryan Paul (author), Reveille, John D. (author), Evans, David M. (author), De Bakker, Paul I W (author), Brown, Matthew A. (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
UNFOLDED PROTEIN RESPONSE
GENOME-WIDE ASSOCIATION
SUSCEPTIBILITY LOCI
TRANSGENIC RATS
ENDOPLASMIC-RETICULUM
BEHCETS-DISEASE
HLA-B27
HLA
MHC
ANTIGEN
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Texto completo:https://doi.org/10.1038/ncomms8146
País:Portugal
Oai:oai:run.unl.pt:10362/23365

Texto Completo

https://doi.org/10.1038/ncomms8146

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