Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B∗27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,64...

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Bibliographic Details
Main Author: Cortes, Adrian (author)
Other Authors: Pulit, Sara L. (author), Leo, Paul J. (author), Pointon, Jenny J. (author), Robinson, Philip C. (author), Weisman, Michael H. (author), Ward, Michael (author), Gensler, Lianne S. (author), Zhou, Xiaodong (author), Garchon, Henri Jean (author), Chiocchia, Gilles (author), Nossent, Johannes (author), Lie, Benedicte A. (author), Førre, Øystein (author), Tuomilehto, Jaakko (author), Laiho, Kari (author), Bradbury, Linda A. (author), Elewaut, Dirk (author), Burgos-Vargas, Ruben (author), Stebbings, Simon (author), Appleton, Louise (author), Farrah, Claire (author), Lau, Jonathan (author), Haroon, Nigil (author), Mulero, Juan (author), Blanco, Francisco J. (author), Gonzalez-Gay, Miguel A. (author), Lopez-Larrea, C. (author), Bowness, Paul (author), Gaffney, Karl (author), Gaston, Hill (author), Gladman, Dafna D. (author), Rahman, Proton (author), Maksymowych, Walter P. (author), Crusius, J. Bart A (author), Van Der Horst-Bruinsma, Irene E. (author), Valle-Oñate, Raphael (author), Romero-Sánchez, Consuelo (author), Hansen, Inger Myrnes (author), Pimentel-Santos, Fernando M. (author), Inman, Robert D. (author), Martin, Javier (author), Breban, Maxime (author), Wordsworth, Bryan Paul (author), Reveille, John D. (author), Evans, David M. (author), De Bakker, Paul I W (author), Brown, Matthew A. (author)
Format: article
Language:eng
Published: 2017
Subjects:
UNFOLDED PROTEIN RESPONSE
GENOME-WIDE ASSOCIATION
SUSCEPTIBILITY LOCI
TRANSGENIC RATS
ENDOPLASMIC-RETICULUM
BEHCETS-DISEASE
HLA-B27
HLA
MHC
ANTIGEN
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Online Access:https://doi.org/10.1038/ncomms8146
Country:Portugal
Oai:oai:run.unl.pt:10362/23365

Internet

https://doi.org/10.1038/ncomms8146

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