Modelling the onset of senescence at the G1/S cell cycle checkpoint

DNA damage (single or double-strand breaks) triggers adapted cellular responses. These responses are elicited through signalling pathways, which activate cell cycle checkpoints and basically lead to three cellular fates: cycle arrest promoting DNA repair, senescence (permanent arrest) or cell death....

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Bibliographic Details
Main Author: Mombach, José CM (author)
Other Authors: Bugs, Cristhian A (author), Chaouiya, Claudine (author)
Format: article
Language:eng
Published: 2015
Subjects:
Signalling network
Logical modelling
Senescence
DNA-damage
Cell fate
Cell cycle checkpoint
Online Access:http://hdl.handle.net/10400.7/339
Country:Portugal
Oai:oai:arca.igc.gulbenkian.pt:10400.7/339

Internet

http://hdl.handle.net/10400.7/339

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