Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats

Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)–mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC)....

ver descrição completa

Detalhes bibliográficos
Autor principal: Ferreira, Ana (author)
Outros Autores: Rodrigues, Márcio (author), Marques, Alexandre (author), Falcão, Amílcar (author), Alves, Gilberto (author)
Formato: article
Idioma:eng
Publicado em: 2017
Assuntos:
(-)-Epigallocatechin gallate
Licarbazepine
Oxcarbazepine
P-glycoprotein
Pharmacokinetics
Silymarin
Texto completo:http://hdl.handle.net/10314/3720
País:Portugal
Oai:oai:bdigital.ipg.pt:10314/3720

Texto Completo

http://hdl.handle.net/10314/3720

Registos relacionados