Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids, on the pharmacokinetics of oxcarbazepine in rats

Considering the potential of flavonoids in reversing the P-glycoprotein (P-gp)–mediated multidrug resistance, this work aimed to assess the combined effects of silymarin and (-)-epigallocatechin gallate (EPG) on the pharmacokinetics of the P-gp substrates oxcarbazepine (OXC) and licarbazepine (LIC)....

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Bibliographic Details
Main Author: Ferreira, Ana (author)
Other Authors: Rodrigues, Márcio (author), Marques, Alexandre (author), Falcão, Amílcar (author), Alves, Gilberto (author)
Format: article
Language:eng
Published: 2017
Subjects:
(-)-Epigallocatechin gallate
Licarbazepine
Oxcarbazepine
P-glycoprotein
Pharmacokinetics
Silymarin
Online Access:http://hdl.handle.net/10314/3720
Country:Portugal
Oai:oai:bdigital.ipg.pt:10314/3720

Internet

http://hdl.handle.net/10314/3720

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