Enhanced solid-state stability of amorphous ibrutinib formulations prepared by hot-melt extrusion

One of the applications of Hot-Melt Extrusion (HME) is the stabilization of amorphous drugs through its incorporation into polymeric blends in the form of Amorphous Solid Dispersions (ASDs). In this study, HME was applied to solve a real problem in the development of an ibrutinib product, stabilizin...

ver descrição completa

Detalhes bibliográficos
Autor principal: Simões, Marta F. (author)
Outros Autores: Nogueira, Bernardo A. (author), Tabanez, Andreia M. (author), Rui Fausto (author), Pinto, Rui M. A. (author), Simões, Sérgio (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Amorphous solid dispersions
Hot-melt extrusion
Ibrutinib
Multivariate statistics
Polymers
Principal components analysis
Texto completo:http://hdl.handle.net/10316/91157
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/91157

Texto Completo

http://hdl.handle.net/10316/91157

Registos relacionados