uORF-mediated translational regulation of PERK : implications for cell homeostasis and human disease

Upstream open reading frames (uORFs) are cis-acting elements located within the 5’ leader sequence (or 5’ untranslated region; 5’UTR) of transcripts that can regulate translation of the correspondent main open reading frame (mORF). During basal conditions, uORFs are typically considered to be repres...

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Bibliographic Details
Main Author: Fernandes, Rafael (author)
Format: doctoralThesis
Language:eng
Published: 2020
Subjects:
AUG-upstream open reading frame (AUG-uORF)
non-AUG-upstream open reading frame (non-AUG-uORF)
endoplasmic reticulum (ER) stress
unfolded protein response
integrated stress response
Wolcott-Rallison Syndrome
Domínio/Área Científica::Ciências Naturais::Ciências Biológicas
Online Access:http://hdl.handle.net/10451/48530
Country:Portugal
Oai:oai:repositorio.ul.pt:10451/48530

Internet

http://hdl.handle.net/10451/48530

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