Tacrine and its analogues impair mitochondrial function and bioenergetics : a lipidomic analysis in rat brain

Tacrine is an acetylcholinesterase inhibitor used as cognitive enhancer in Alzheimer's disease treatment. However, the low therapeutic efficiency and the high incidence of side effects have limited its clinical use. In the present study, the molecular mechanisms underlying the brain activity of...

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Bibliographic Details
Main Author: Melo, Tânia (author)
Other Authors: Videira, Romeu (author), André, Sónia (author), Maciel, Elisabete (author), Francisco, Carla Santana (author), Campos, Ana M. F. Oliveira (author), Rodrigues, Lígia M. (author), Domingues, M. R. M. (author), Peixoto, Francisco (author), Oliveira, M. Manuel (author)
Format: article
Language:eng
Published: 2012
Subjects:
Non-synaptic brain mitochondria
Lipidomics
Bioenergetic activity
Tacrine
Alzheimer disease
Alzheimer's disease
Science & Technology
Online Access:http://hdl.handle.net/1822/21998
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/21998

Internet

http://hdl.handle.net/1822/21998

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