Tacrine and its analogues impair mitochondrial function and bioenergetics : a lipidomic analysis in rat brain

Tacrine is an acetylcholinesterase inhibitor used as cognitive enhancer in Alzheimer's disease treatment. However, the low therapeutic efficiency and the high incidence of side effects have limited its clinical use. In the present study, the molecular mechanisms underlying the brain activity of...

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Detalhes bibliográficos
Autor principal: Melo, Tânia (author)
Outros Autores: Videira, Romeu (author), André, Sónia (author), Maciel, Elisabete (author), Francisco, Carla Santana (author), Campos, Ana M. F. Oliveira (author), Rodrigues, Lígia M. (author), Domingues, M. R. M. (author), Peixoto, Francisco (author), Oliveira, M. Manuel (author)
Formato: article
Idioma:eng
Publicado em: 2012
Assuntos:
Non-synaptic brain mitochondria
Lipidomics
Bioenergetic activity
Tacrine
Alzheimer disease
Alzheimer's disease
Science & Technology
Texto completo:http://hdl.handle.net/1822/21998
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/21998

Texto Completo

http://hdl.handle.net/1822/21998

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