Optimal control and sensitivity analysis of a fractional order TB model

A Caputo fractional-order mathematical model for the transmission dynamics of tuberculosis (TB) was recently proposed in [Math. Model. Nat. Phenom. 13 (2018), no. 1, Art. 9]. Here, a sensitivity analysis of that model is done, showing the importance of accuracy of parameter values. A fractional opti...

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Detalhes bibliográficos
Autor principal: Rosa, Silvério (author)
Outros Autores: Torres, Delfim F. M. (author)
Formato: article
Idioma:eng
Publicado em: 2019
Assuntos:
Texto completo:http://hdl.handle.net/10773/26479
País:Portugal
Oai:oai:ria.ua.pt:10773/26479
Descrição
Resumo:A Caputo fractional-order mathematical model for the transmission dynamics of tuberculosis (TB) was recently proposed in [Math. Model. Nat. Phenom. 13 (2018), no. 1, Art. 9]. Here, a sensitivity analysis of that model is done, showing the importance of accuracy of parameter values. A fractional optimal control (FOC) problem is then formulated and solved,with the rate of treatment as the control variable. Finally, a cost-effectiveness analysis is performed to assess the cost and the effectiveness of the control measures during the intervention, showing in which conditions FOC is useful with respect to classical (integer-order) optimal control.