Functionalized chitosan derivatives as nonviral vectors: Physicochemical properties of acylated N,N,N-trimethyl chitosan/oligonucleotide nanopolyplexes

Cationic polymers have recently attracted attention due to their proven potential for nonviral gene delivery. In this study, we report novel biocompatible nanocomplexes produced using chemically functionalized N,N,N-trimethyl chitosan (TMC) with different N-acyl chain lengths (C 5 -C 18 ) associated...

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Bibliographic Details
Main Author: Santos, J (author)
Other Authors: Moreno, PM (author), Mansur, A (author), Leiro, V (author), Mansur, H (author), Pêgo, AP (author)
Format: article
Language:eng
Published: 2015
Subjects:
Cell Survival/drug effects
Chitosan/chemistry
Chitosan/metabolism
Chitosan/toxicity
Dynamic Light Scattering
Fatty Acids/chemistry
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Nanoparticles/chemistry
Nanoparticles/toxicity
Oligonucleotides/chemistry
Oligonucleotides/metabolism
Spectroscopy, Fourier Transform Infrared
Transfection
Online Access:https://hdl.handle.net/10216/120738
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120738

Internet

https://hdl.handle.net/10216/120738

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