Effect of farnesol on Candida dubliniensis morphogenesis
Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. m...
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| Outros Autores: | , , |
| Formato: | article |
| Idioma: | eng |
| Publicado em: |
2007
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| Assuntos: | |
| Texto completo: | http://hdl.handle.net/1822/6062 |
| País: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/6062 |
| Resumo: | Cell–cell signalling in Candida albicans is a known phenomenon and farnesol was identified as a quorum sensing molecule determining the yeast morphology. The aim of this work was to verify if farnesol had a similar effect on Candida dubliniensis, highlighting the effect of farnesol on Candida spp. morphogenesis. Methods and Results: Two different strains of C. dubliniensis and one of C. albicans were grown both in RPMI 1640 and in serum in the presence of absence of farnesol. At 150 μmol l -1 farnesol the growth rate of both Candida species was not affected. On the contrary, farnesol inhibited hyphae and pseudohyphae formation in C. dubliniensis. Conclusion: Farnesol seems to mediate cell morphology in both Candida species. Significance and Impact of the Study: The effect of farnesol on C. dubliniensis morphology was not reported previously. |
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