Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin

Familial amyloidotic polyneuropathy (FAP) is an autosomal dominant hereditary type of amyloidosis involving amino acid substitutions in transthyretin (TTR). V30M-TTR is the most frequent variant, and L55P-TTR is the variant associated with the most aggressive form of FAP. The thermal stability of th...

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Bibliographic Details
Main Author: Shnyrov, Valery L. (author)
Other Authors: Villar, Enrique (author), Zhadan, Galina G. (author), Sanchez-Ruiz, Jose M. (author), Quintas, Alexandre (author), Saraiva, Maria João M. (author), Brito, Rui M. M. (author)
Format: article
Language:eng
Published: 2000
Subjects:
Transthyretin
Familial amyloidotic polyneuropathy
Differential scanning calorimetry
Thermal stability
Online Access:http://hdl.handle.net/10316/5234
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5234

Internet

http://hdl.handle.net/10316/5234

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