A Pyranoxanthone as a potent antimitotic and sensitizer of cancer cells to low doses of Paclitaxel

Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors...

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Bibliographic Details
Main Author: França, Fábio (author)
Other Authors: Silva, Patrícia M. A. (author), Soares, José X. (author), Henriques, Ana C. (author), Loureiro, Daniela R. P. (author), Azevedo, Carlos M. G. (author), Afonso, Carlos M. M. (author), Bousbaa, Hassan (author)
Format: article
Language:eng
Published: 2021
Subjects:
Paclitaxel
Cancer
Pyranoxanthone
Antitumor
Mitosis
Apoptosis
Online Access:http://hdl.handle.net/10400.1/14967
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/14967

Internet

http://hdl.handle.net/10400.1/14967

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