BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimally invasive intramuscular admi...

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Bibliographic Details
Main Author: Lopes, CDF (author)
Other Authors: Gonçalves, NP (author), Gomes, CP (author), Saraiva, MJ (author), Pêgo, AP (author)
Format: article
Language:eng
Published: 2017
Subjects:
Animals
Brain-Derived Neurotrophic Factor/genetics
Female
Genetic Therapy/methods
Mice
Mice Inbred BALB C
Nanocapsules/administration & dosage
Nanocapsules/chemistry
Neurons/chemistry
Peripheral Nerve Injuries/genetics
Peripheral Nerve Injuries/pathology
Peripheral Nerve Injuries/therapy
Plasmids/administration & dosage
Plasmids/genetics
Treatment Outcome
Online Access:http://hdl.handle.net/10216/110343
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110343

Internet

http://hdl.handle.net/10216/110343

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