Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

This study was aimed at investigating the effects of subchronic administration of doxorubicin (DOX) on brain mitochondrial bioenergetics and oxidative status. Rats were treated with seven weekly injections of vehicle (sc, saline solution) or DOX (sc, 2 mg kg−1), and 1 week after the last administrat...

ver descrição completa

Detalhes bibliográficos
Autor principal: Cardoso, Susana (author)
Outros Autores: Santos, Renato X. (author), Carvalho, Cristina (author), Correia, Sónia (author), Pereira, Gonçalo C. (author), Pereira, Susana S. (author), Oliveira, Paulo J. (author), Santos, Maria S. (author), Proença, Teresa (author), Moreira, Paula I. (author)
Formato: article
Idioma:eng
Publicado em: 2008
Assuntos:
Doxorubicin
Mitochondria
Oxidative stress
Permeability transition pore
Free radicals
brain
Animals
Antioxidants
Brain
Calcium
Glutathione
Male
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
Oxidation-Reduction
Oxidative Stress
Rats
Rats, Wistar
Vitamin E
Texto completo:http://hdl.handle.net/10316/10086
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/10086

Texto Completo

http://hdl.handle.net/10316/10086

Registos relacionados