Doxorubicin increases the susceptibility of brain mitochondria to Ca2+-induced permeability transition and oxidative damage

This study was aimed at investigating the effects of subchronic administration of doxorubicin (DOX) on brain mitochondrial bioenergetics and oxidative status. Rats were treated with seven weekly injections of vehicle (sc, saline solution) or DOX (sc, 2 mg kg−1), and 1 week after the last administrat...

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Bibliographic Details
Main Author: Cardoso, Susana (author)
Other Authors: Santos, Renato X. (author), Carvalho, Cristina (author), Correia, Sónia (author), Pereira, Gonçalo C. (author), Pereira, Susana S. (author), Oliveira, Paulo J. (author), Santos, Maria S. (author), Proença, Teresa (author), Moreira, Paula I. (author)
Format: article
Language:eng
Published: 2008
Subjects:
Doxorubicin
Mitochondria
Oxidative stress
Permeability transition pore
Free radicals
brain
Animals
Antioxidants
Brain
Calcium
Glutathione
Male
Mitochondrial Membrane Transport Proteins
Mitochondrial Permeability Transition Pore
Oxidation-Reduction
Oxidative Stress
Rats
Rats, Wistar
Vitamin E
Online Access:http://hdl.handle.net/10316/10086
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/10086

Internet

http://hdl.handle.net/10316/10086

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